Bone microarchitecture and structure in patients with AS Previous studies on bone microarchitecture and structure in patients with AS Not much is known about the microarchitecture of bone in AS. In 1992, Devogelaer and colleagues studied 10 patients with AS by using...
Diagnosis of bone loss in AS Use of DXA in AS Currently there is no accurate measure of overall bone strength. BMD measured by DXA is utilized as a surrogate measure of bone strength. However, osteoporosis is characterized by compromised bone strength and high...
Management of osteoporosis in AS No specific guidelines are available for managing bone loss in AS. Present clinical practice guidelines in Canada involve applying FRAX or CAROC based guidelines to evaluate fracture risk (Kanis 2011,Papaioannou 2010). These guidelines...
Prevalence of fractures Osteoporosis has serious consequences, such as fractures. Fractures can cause severe pain, physical deformity, disability, poor quality of life and even mortality. In addition, they are sometimes associated with a need for long-term care...
Bone loss in AS It is now well established that patients with AS are at high risk of developing osteoporosis (Davey-Ranasinghe 2013). The prevalence of osteoporosis and osteopenia in ankylosing spondylitis, as assessed by cross sectional studies, varies from 2- 34%...
Clinical features of AS AS has a chronic disabling disease course and it affects multiple organ-systems. The onset of disease is predominantly in the teenage years and twenties. The onset at a young age exposes patients to a prolonged burden of disease. It is more...
Definition of AS Ankylosing spondylitis (AS) is a chronic systemic inflammatory disease. It predominantly affects the axial skeleton and sacroiliac joints. AS is also the prototypic disorder of a spectrum of diseases called spondyloarthritis (SpA). AS is considered as...
